Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes

Autor: Yu Kuei Lin, Emily Tanner, Yuee Wang, Wen Ye, Lynn Ang, Wenjun Ju, Rodica Pop‐Busui
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 14, Iss 10, Pp 1183-1186 (2023)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.14049
Popis: Abstract The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker.
Databáze: Directory of Open Access Journals
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