A cross-sectional study to identify a set of risk factors for caprine herpesvirus 1 infection

Autor: S. Bertolini, A. Rosamilia, C. Caruso, C. Maurella, F. Ingravalle, A. Quasso, P. L. Acutis, M. Pitti, L. Masoero, G. Ru
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-7 (2018)
Druh dokumentu: article
ISSN: 1746-6148
DOI: 10.1186/s12917-018-1401-8
Popis: Abstract Background Caprine herpesvirus 1 (CpHV-1) causes neonatal mortality and reproductive failure in goats. Despite its impact on herd reproductive performance, few studies have investigated the risk factors associated with CpHV-1 infection. The aim of this cross-sectional study was to identify potential herd- and host-level risk factors associated with CpHV-1 prevalence in a goat population with heterogeneous seropositivity for CpHV-1. Results Blood samples and individual data from 4542 goats were collected from 255 herds in Piedmont, Italy. Enzyme-linked immunosorbent assay (ELISA) and serum neutralization tests were carried out to detect antibodies against CpHV-1. A mixed-effects model was applied to identify any statistical association between CpHV-1 seropositivity and a set of putative host-level and herd-level risk factors. A total of 630 samples tested were found positive by ELISA (prevalence = 13.9%; 95% confidence interval (CI) 12.9–14.9). Of the 255 tested herds, 85 were classified as positive for the presence of at least one gB-positive animal (herd prevalence 33.3%, 95% CI 27.5–39.2), with a within-herd prevalence between 0.7 and 100% (Q1 = 17.6%; median = 32.3%; Q3 = 50%) (Q = quartiles). The prevalence ratios showed a statistical association with the following risk factors: breeds other than Saanen, older age, larger herd size, meat and extensive herds, and co-existence of CAEV-infected animals. Conclusions Results from this cross sectional study may help to elucidate the natural history of the infection and inform targeted strategies to control a disease with a potentially important impact on animal health and goat farming economy.
Databáze: Directory of Open Access Journals
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