CLINICAL AND PARACLINICAL FEATURES AND PATHOPHYSIOLOGICAL MECHANISMS OF DIGESTIVE SYSTEM DISORDERS IN PREMATURE INFANTS WITH PERINATAL PATHOLOGY
| Autor: | Ю. Годованець, T. Дроник |
|---|---|
| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Неонатологія, хірургія та перинатальна медицина, Vol 8, Iss 3(49) (2023) |
| Druh dokumentu: | article |
| ISSN: | 2413-4260 2226-1230 |
| DOI: | 10.24061/2413-4260.XIII.3.49.2023.5 |
| Popis: | Introduction. According to the World Health Organization (WHO), the incidence of preterm birth is 10-15%, or about 15 million newborns worldwide, and this number is increasing. The highest incidence of morbidity and mortality is observed in infants born before 32 weeks of gestation. Among other things, preterm infants have an immature digestive system, which leads to food intolerance. The formation of cumulative nutrient defi ciencies in the digestive system from birth puts children at risk of delayed psychophysical development and contributes to the development of negative long-term neurological consequences. Many of these complications have lifelong consequences for health, growth and development, both in infancy and later in life. Aim of the study. To improve the diagnosis of intestinal dysfunction in perinatal pathology in premature infants based on the study of risk factors and clinical and laboratory parameters. Materials and methods of the study. A comprehensive clinical and paraclinical examination of 91 premature infants with clinical manifestations of moderate and severe perinatal pathology with signs of disturbances of the functional state of the digestive system (group I, gestational age 29 (0/7) – 36 (6/7) weeks) and 57 conditionally healthy newborns (group II, gestational age 35 (0/7) – 36 (6/7) weeks) was performed. The total number of children studied was 148. Exclusion criteria were children with congenital malformations and septic conditions. The list of laboratory parameters used included: levels of α-1-antitrypsin (A1AT), PMN-elastase, albumin, fecal calprotectin (FC) and fecal elastase-1 (FE-1) in children’s stool using enzyme- linked immunosorbent assay (ELISA), reagents from Immundiagnostic AG (Germany) on the basis of the German- Ukrainian laboratory “BUKINMED” (Chernivtsi, Ukraine). The scientifi c work was carried out on the basis of neonatology departments of the Chernivtsi City Clinical Maternity Hospital in 2014-2018. Informed consent of the parents of the child was obtained with adequate explanation of the purpose, objectives, methods and scope of laboratory and instrumental research methods. The study protocol was approved by the Biomedical Ethics Commission of the Bukovinian State Medical University, 2015. The studies were conducted in accordance with the basic provisions of GCP (1996), the Convention of the Council of Europe on Human Rights and Biomedicine (April 4, 1997), the World Medical Association Declaration of Helsinki on Ethical Principles for Research Involving Human Subjects (1964-2008), Order of the Ministry of Health of Ukraine ¹ 690 dated September 23, 2009 (as amended by Order of the Ministry of Health of Ukraine ¹ 523 dated July 12, 2012). Statistical processing of data was performed using the software “STATISTICA” (StatSoft Inc., USA, version 10), program MedCalc (https://www.medcalc. org/index.php). Comparison of quantitative indicators with normal distribution was performed using Student’s t-test. The diff erence in parameters was considered statistically signifi cant at p |
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