| Autor: |
Kenta Tsutsui, MD, Satoshi Yamagishi, MD, Tomoyuki Kunishima, MD, Noriyuki Hayami, MD, Yuji Murakawa, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Journal of Arrhythmia, Vol 30, Iss 3, Pp 157-160 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1880-4276 |
| DOI: |
10.1016/j.joa.2013.06.002 |
| Popis: |
Background: Some cardioactive vasodilating agents inhibit ventricular tachyarrhythmias (VT) associated with acquired long QT syndrome (LQT). We tested whether a vasodilator without direct cardiac effect can eliminate abnormal repolarization-related VT. Methods: The effect of hydralazine on the occurrence of VT was assessed in a methoxamine-sensitized rabbit model of acquired LQT. To verify that VTs in this animal model are triggered by early afterdepolarization (EAD), monophasic action potential (MAP) on the left ventricular surface was recorded in open-chest rabbits. Results: In control rabbits, combined administration of methoxamine and nifekalant frequently induced VTs (16/20, 80%). In contrast, VT occurred only in 2 out of 14 rabbits treated with hydralazine (14.3%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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