Evaluation of soluble mesothelin-related peptides and MSLN genetic variability in asbestos-related diseases

Autor: Goricar Katja, Kovac Viljem, Dodic-Fikfak Metoda, Dolzan Vita, Franko Alenka
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Radiology and Oncology, Vol 54, Iss 1, Pp 86-95 (2020)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2020-0011
Popis: Asbestos exposure is associated with increased risk of several diseases, including malignant mesothelioma (MM). Cell surface glycoprotein mesothelin is overexpressed in MM and serum soluble mesothelin-related peptides (SMRP) were already proposed as a diagnostic or prognostic biomarker in MM. However, interindividual variability in serum SMRP levels limits the clinical usefulness. Our primary objective was to investigate the influence of MSLN rs1057147 on serum SMRP levels in asbestos-exposed subjects and patients with asbestos-related diseases as well as on survival in MM.
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