| Popis: |
Laura S Gold,1,2 Tara A Nazareth,3 Tzy-Chyi Yu,3 Keith R Fry,3 Nancy Ho Mahler,3 Andrew Rava,3 Royce W Waltrip II,3 Ryan N Hansen2,4 1Department of Radiology, University of Washington, Seattle, WA, USA; 2CHOICE Institute, School of Pharmacy, University of Washington, Seattle, WA, USA; 3Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA; 4Department of Health Services, University of Washington, Seattle, WA, USACorrespondence: Laura S GoldDepartment of Radiology, University of Washington, Box 359558, Seattle, WA 98195-9558, USATel +1 206-543-2749Fax +1 206-543-8609Email goldl@uw.eduIntroduction: Infantile spasms (IS) is a rare and devastating form of early childhood epilepsy. Two drugs are approved in the United States for treatment of IS, H.P. Acthar® Gel (repository corticotropin injection, RCI) and Sabril® (vigabatrin). Given real-world variation in treatment of patients with IS, this study characterized treatment patterns with IS medications and determined all-cause health care resource utilization (HCRU) during the 90 days before initiating therapy with RCI in patients with IS.Materials and methods: Truven Health MarketScan® Research Databases were used to identify commercially insured US patients 1 drug class before RCI initiation. Other AEDs were dispensed most often, either alone (31.3%) or with other drug classes (9.3%). Mean HCRU included 11.8 all-cause outpatient visits and 4.5 medications dispensed. Patients who received RCI or corticosteroids as their initial IS treatment had the lowest and second-lowest HCRU.Conclusion: In the 90 days before initiating RCI, patients with IS received multiple diagnoses and treatments, characterized by frequent HCRU. Use of RCI first (no prior IS medications) and AEDs first were associated with the lowest and highest HCRU, respectively, across all categories (all-cause outpatient visits, emergency department visits, hospital admissions, prescription medications).Keywords: Infantile spasms, early diagnosis, early treatment, health care resource utilization, medication patterns |
