Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels

Autor: C. Bottomley, M. Otiende, S. Uyoga, K. Gallagher, E. W. Kagucia, A. O. Etyang, D. Mugo, J. Gitonga, H. Karanja, J. Nyagwange, I. M. O. Adetifa, A. Agweyu, D. J. Nokes, G. M. Warimwe, J. A. G. Scott
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26452-z
Popis: The proportion of a population that has previously been infected by a pathogen is typically estimated using antibody thresholds adjusted for sensitivity and specificity. Here, the authors present a model-based alternative to threshold methods which accounts for antibody waning and other sources of spectrum bias.
Databáze: Directory of Open Access Journals