CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells

Autor:	J. Boutin, J. Rosier, D. Cappellen, F. Prat, J. Toutain, P. Pennamen, J. Bouron, C. Rooryck, J. P. Merlio, I. Lamrissi-Garcia, G. Cullot, S. Amintas, V. Guyonnet-Duperat, C. Ged, J. M. Blouin, E. Richard, S. Dabernat, F. Moreau-Gaudry, A. Bedel
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Science
Zdroj:	Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Druh dokumentu:	article
ISSN:	2041-1723
DOI:	10.1038/s41467-021-25190-6
Popis:	CRISPR-Cas9 generates double-strand breaks, which pose a threat to genome integrity. Here the authors show loss of heterozygosity in edited hematopoietic progenitor cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e2a0368b510f4b0f8a6f33bea02556ca Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ