| Autor: |
Yun Jung Hur, Seung-Ah Choe, Young June Choe, Jinyoung Paek |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 104, Iss , Pp 551-555 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2020.11.147 |
| Popis: |
Objectives: We estimated the impact of universal hepatitis B immunization using 18-year data of women who are of childbearing age in South Korea. Methods: We used hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) data of 145,993 women aged 20–49 years during 2001–2018 at the Gangnam CHA Medical Center. Annual prevalences of HBsAg and anti-HBs positivity were calculated and tested for linear trend. We conducted age-period-cohort (APC) analysis to obtain period and cohort effect. Results: Overall proportion of HBsAg positivity was 3.5% (n = 5050) and anti-HBs positivity was 75.3% (n = 109,907) during the study period. HBsAg positivity percentage decreased from 5.1% in 2001 to 2.5% in 2018 (P < 0.001) while anti-HBs positivity increased from 59.9% to 75.8% (P = 0.002). Average annual percent change of HBsAg positivity was −5.9% (95% confidence interval (CI): −6.9%, −4.8%). The period and cohort RR curve identified a consistent decrease in HBsAg positivity over time and across generations. Conclusions: We observed a concurrent decrease in HBsAg and an increase in anti-HBs seropositivity among Korean women of childbearing age, implicating success in preventing vertical transmission. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
