| Autor: |
Wei Ma, Bin Wang, Dun Wang, Ying Liu, Ming-Chao Jiang, Jin-Yan Zhang, Dong-Dong Peng, Zhi-Cheng Li, Cui-Yun Yu, Hua Wei |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Supramolecular Materials, Vol 3, Iss , Pp 100066- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-2405 |
| DOI: |
10.1016/j.supmat.2024.100066 |
| Popis: |
Chemodynamic therapy, which relies on the generation of cytotoxic radicals, can be amplified by a nanoplatform that produces hydroxyl radicals while also compromising natural radical scavenging mechanisms. For this purpose, a well-defined amphiphilic terpolymer, poly(oligo(ethylene glycol) monomethyl ether methacrylate)-block-poly(N,N-dimethyl aminoethyl methacrylate-statistical-monomer bearing ferrocene graft via azobenzene linker) (POEGMA-b-P(DMAEMA-st-(M-Azo-Fc), denoted as PAzo-Fc) is prepared by a consecutive reversible addition-fragmentation chain transfer (RAFT) polymerization technique, and is further used for doxorubicin (DOX) encapsulation to afford DOX-loaded stabilized nanomicelles, DOX@PAzo-Fc with an average hydrodynamic diameter of 86.0 nm. DOX@PAzo-Fc shows a self-cascade property for amplified CDT. That is, Azo cleavage-induced glutathione (GSH) depletion alleviates reactive oxygen species (ROS) scavenging. Together with the DOX-enhanced hydrogen peroxide generation, the Fc-mediated Fenton reaction is boosted for enhanced CDT. More importantly, the resulting amplified cascade chemo-chemodynamic therapy exerts a synergistic immunogenic cell death (ICD) enhancement effect for effective cancer immunotherapy, which further resulted in a high tumor inhibition rate of 87.8 % in murine tumor models. The uniqueness of this study is the construction of a minimalist nanoplatform based on M-Azo-Fc units for amplified CDT via simultaneously producing hydroxyl radicals and compromising natural radical scavenging mechanisms. Overall, this self-cascade terpolymer platform fabricated herein offers a facile yet robust approach for advanced combinatory cancer therapy with great potential for clinical translations. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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