Uncertainty propagation and sensitivity analysis: results from the Ocular Mathematical Virtual Simulator

Autor: Christophe Prud'homme, Lorenzo Sala, Marcela Szopos
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Mathematical Biosciences and Engineering, Vol 18, Iss 3, Pp 2010-2032 (2021)
Druh dokumentu: article
ISSN: 1551-0018
DOI: 10.3934/mbe.2021105
Popis: We propose an uncertainty propagation study and a sensitivity analysis with the Ocular Mathematical Virtual Simulator, a computational and mathematical model that predicts the hemodynamics and biomechanics within the human eye. In this contribution, we focus on the effect of intraocular pressure, retrolaminar tissue pressure and systemic blood pressure on the ocular posterior tissue vasculature. The combination of a physically-based model with experiments-based stochastic input allows us to gain a better understanding of the physiological system, accounting both for the driving mechanisms and the data variability.
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