| Autor: |
Kavish R. Patidar, Jennifer L. Peng, Harleen Kaur, Astin Worden, Carla D. Kettler, Francis Pike, Caitriona A. Buckley, Eric S. Orman, Archita P Desai, Lauren D. Nephew, Chandrashekhar A. Kubal, Samer Gawrieh, Naga Chalasani, Marwan S. Ghabril |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Hepatology Communications, Vol 6, Iss 5, Pp 1090-1099 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2471-254X |
| DOI: |
10.1002/hep4.1874 |
| Popis: |
Differences in mortality between critically ill patients with severe alcohol‐associated hepatitis (sAH) and acute‐on‐chronic liver failure (ACLF) and non‐sAH ACLF (i.e., ACLF not precipitated by sAH) are unknown. Such differences are important, as they may inform on prognosis and optimal timing of liver transplantation (LT). Thus, we aimed to compare short‐term and longer‐term mortality between patients with sAH ACLF and patients with non‐sAH ACLF who were admitted to the intensive care unit. Patients with ACLF admitted from 2016‐2018 at two tertiary care intensive care units were analyzed. SAH was defined by the National Institute on Alcohol Abuse and Alcoholism’s Alcoholic Hepatitis Consortium and Model for End‐Stage Liver Disease score >20. Mortality without LT was compared between sAH ACLF and non‐sAH ACLF using Fine and Gray’s competing‐risks regression. A total of 463 patients with ACLF (18% sAH and 82% non‐sAH) were included. Compared to patients with non‐sAH ACLF, patients with sAH ACLF were younger (49 vs. 56 years; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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