Capillary rarefaction during bed rest is proportionally less than fibre atrophy and loss of oxidative capacity

Autor: Paul William Hendrickse, Rob C.I. Wüst, Bergita Ganse, Ifigeneia Giakoumaki, Jörn Rittweger, Alessandra Bosutti, Hans Degens
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 2712-2723 (2022)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13072
Popis: Abstract Background Muscle disuse from bed rest or spaceflight results in losses in muscle mass, strength and oxidative capacity. Capillary rarefaction may contribute to muscle atrophy and the reduction in oxidative capacity during bed rest. Artificial gravity may attenuate the negative effects of long‐term space missions or bed rest. The aim of the present study was to assess (1) the effects of bed rest on muscle fibre size, fibre type composition, capillarization and oxidative capacity in the vastus lateralis and soleus muscles after 6 and 55 days of bed rest and (2) the effectiveness of artificial gravity in mitigating bed‐rest‐induced detriments to these parameters. Methods Nineteen participants were assigned to a control group (control, n = 6) or an intervention group undergoing 30 min of centrifugation (n = 13). All underwent 55 days of head‐down tilt bed rest. Vastus lateralis and soleus biopsies were taken at baseline and after 6 and 55 days of bed rest. Fibre type composition, fibre cross‐sectional area, capillarization indices and oxidative capacity were determined. Results After just 6 days of bed rest, fibre atrophy (−23.2 ± 12.4%, P
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