Successful experience in treating primary cutaneous anaplastic large cell lymphoma occuring with common lesions of the skin and lung tissue
| Autor: | N. G. Chernova, D. S. Badmazhapova, A. M. Kovrigina, A. E. Karamova, A. A. Vorontsova, M. N. Sinitcina, Yu. V. Sidorova, L. A. Grebenyuk, M. A. Nefedova, L. F. Znamenskaya, E. E. Zvonkov, V. G. Savchenko |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Vestnik Dermatologii i Venerologii, Vol 94, Iss 4, Pp 30-42 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0042-4609 2313-6294 |
| DOI: | 10.25208/0042-4609-2018-94-4-30-42 |
| Popis: | The aim of the study is to present a successful case in treating primary cutaneous anaplastic large cell lymphoma (PCALCL) occurring with common lesions of the skin and lung tissue.Materials and methods. For the verification of the diagnosis in a patient with three types of skin elements (spot, thin plaque with and without ulceration), differential diagnosis was performed between ulcerative pyoderma gangrenosum, PCALCL, large-cell transformation of mycosis fungoides, and secondary skin lesions under the nodal ALK-negtaive ALCL. A complex of studies, including histological, immunohisto - chemical, cytogenetic studies of skin tumor biopsy, allowed the verification of the PCALCL diagnosis. For the treatment of the patient, intensive induction chemotherapy was used followed by high-dose consolidation and autologous transplantation of hematopoietic stem cells.Results. The selected treatment tactics allowed a long-term complete remission of the disease to be achieved in a patient from the poor prognosis group.Conclusion. An algorithm for the differential diagnosis and tactics of treating is presented for a patient with primary anaplastic large cell lymphoma with a widespread skin lesion and extradermal foci. |
| Databáze: | Directory of Open Access Journals |
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