Deliberation concerning the role of M1-type macrophage subset in oral carcinogenesis

Autor:	Chen-xi Li, Zhong-cheng Gong, Jing-wen Yu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	M1–M2 macrophage polarization Oral squamous cell carcinoma Tumor-associated macrophages Porphyromonas gingivalis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-4 (2024)
Druh dokumentu:	article
ISSN:	1756-9966
DOI:	10.1186/s13046-024-03128-2
Popis:	Abstract Over the last decade, accumulating evidence has suggested that tumor-associated macrophages (TAMs) play a significant role in the tumor development. This commentary wishes to highlight the findings by You, et al. that M1-like TAMs could cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma (OSCC) via the IL6/Stat3/THBS1 feedback loop. These unprecedented findings identified M1-like TAMs-regulated processes as potentially tumor-promotion in the context of OSCC immunomicroenvironment.
Databáze:	Directory of Open Access Journals
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