Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective

Autor:	Daniel Martínez-Carballeira, Ángel Bernardo, Alberto Caro, Inmaculada Soto, Laura Gutiérrez
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	antiplatelet antibodies clinical manifestations diagnosis history immune thrombocytopenia (ITP) pathogenesis Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Hematology Reports, Vol 16, Iss 2, Pp 204-219 (2024)
Druh dokumentu:	article
ISSN:	2038-8330
DOI:	10.3390/hematolrep16020021
Popis:	Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in the platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both peripheral destruction of platelets and impaired central megakaryopoiesis and platelet production in the bone marrow. Here, we intend to contextualize the current knowledge on the pathophysiology, terminology, epidemiology, clinical manifestations, diagnosis, and prognosis of ITP from a historical perspective and the first references to the never-stopping garnering of knowledge about this entity. We highlight the necessity to better understand ITP in order to be able to provide ITP patients with personalized treatment options, improving disease prognosis and reducing the incidence or frequency of refractoriness.
Databáze:	Directory of Open Access Journals
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