Prognostic impact of chronological age on efficacy of immune checkpoint inhibitors in non‐small‐cell lung cancer: Real‐world data from 86 173 patients

Autor:	Shinkichi Takamori, Mototsugu Shimokawa, Takefumi Komiya
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	age immune checkpoint inhibitor non‐small‐cell lung cancer programmed cell death‐1 survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 12, Iss 21, Pp 2943-2948 (2021)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.14178
Popis:	Abstract Immune checkpoint inhibitors (ICIs) have become standard pharmacological therapies in patients with non‐small‐cell lung cancer (NSCLC). Because elderly patients with NSCLC are often excluded from clinical trials as a result of lower functional capacity or comorbidities, the prognostic impact of chronological age on the efficacy of ICIs is unclear. The National Cancer Database was queried for stage IV NSCLC patients between 2014 and 2015. Associations between ICI therapy and clinical characteristics were assessed using chi‐squared tests. Kaplan–Meier curves were compared using the log‐rank test. A Cox proportional hazards model was used to identify clinical characteristics predictive of overall survival (OS). This study included 24 136 patients with stage IV NSCLC aged ≥75 years and 62 037 patients with stage IV NSCLC aged
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d29c2360c2114054b9e5913b273d8dc2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF