| Autor: |
Cagdas Colluoglu, Serdar Balci, Betul Gundogdu, Taha Abdulkadir Coban, Seval Bulut, Halis Suleyman |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 17, Iss 3 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| DOI: |
10.3329/bjp.v17i3.59418 |
| Popis: |
This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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