Soluble human leukocyte antigen-G evaluation in pregnant women with gestational diabetes mellitus

Autor: Muhamad R. Abdel Hameed, Osama Ahmed Ibrahiem, Entsar Hamed Ahmed, Paula Rofaeel Sedky, Naglaa Mohamed M. A. Mousa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: The Egyptian Journal of Internal Medicine, Vol 32, Iss 1, Pp 1-6 (2020)
Druh dokumentu: article
ISSN: 1110-7782
2090-9098
DOI: 10.1186/s43162-020-00009-w
Popis: Abstract Background Gestational diabetes mellitus is any degree of glucose intolerance with onset or first recognition occurring late in second trimester and third trimester of pregnancy. It constitutes a greater impact on diabetes epidemic as it carries a major risk for developing type 2 diabetes mellitus to the mother and her fetus later in life. human leukocyte antigen (HLA)-G is a class Ib gene presents in the human major histocompatibility complex (MHC). HLA-G has an important role for mother and fetus tolerance during pregnancy, also in the pancreatic islet cells protection. This is a case-control study, measuring serum HLA-G levels by ELISA in 60 pregnant women with gestational diabetes compared with 36 normal pregnant women. Results HLA-G levels were significantly high in pregnant women with gestational diabetes mellitus (GDM) in contrast to women with normal pregnancy (P = 0.001). Conclusion Women with GDM had significantly higher levels of soluble HLA-G than women without GDM, suggesting that HLA-G molecule is among the factors for regulation and control of the immune response and the induction of tolerance. Soluble HLA-G could be considered an important follow-up investigation for all pregnant primary health care for early detection of gestational diabetes.
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