Epidemiology of potential drug-drug interactions in elderly population admitted to critical care units of Peshawar, Pakistan

Autor: Faisal Shakeel, Muhammad Aamir, Ahmad Farooq Khan, Tayyiba Nader Khan, Samiullah Khan
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-6 (2018)
Druh dokumentu: article
ISSN: 2050-6511
65814177
DOI: 10.1186/s40360-018-0276-4
Popis: Abstract Background Aging population, is a reality in many countries because of improvement in the health care, patient safety and other supplemental factors. Pharmacotherapy in this population must be evaluated due to their higher susceptibility to adverse drug outcomes, like potential drug-drug interactions (PDDIs). Research in this regard is limited particularly in developing countries. The aim of the study was to evaluate the prevalence and associated factors in this population. Methods The multicentered study evaluated the prevalence of potential drug-drug interactions and associated factors in elderly population at critical care units in Peshawar, Pakistan. Potential drug-drug interactions were evaluated using Micromedex DrugReax, while statistical analysis was performed using SPSS. Results A total of 70.17% elderly patients were observed to have at least one PDDI. A significant association was observed between presence of PDDIs and number of prescribed drugs, duration of stay and age (p
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