The history of haploidentical stem cell transplantation: a trip from the bench to the bedside

Autor:	Mariana G. Meade, Javier Bolaños-Meade
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Haploidentical HLA-matched bone marrow transplantation acute graft versus host disease chronic graft versus host disease graft failure Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Hematology, Vol 29, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	16078454 1607-8454
DOI:	10.1080/16078454.2024.2346401
Popis:	ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of the development of haploidentical transplantation at Johns Hopkins University, from the bench to the bedside.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/299bcd33869948dc95e7bf48c65dd776 Zobrazit plný text záznamu View record in DOAJ