Mechanism of partial agonism in AMPA-type glutamate receptors

Autor: Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14327
Popis: Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.
Databáze: Directory of Open Access Journals