The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle

Autor: Timothy R. Howard, Marni S. Crow, Todd M. Greco, Krystal K. Lum, Tuo Li, Ileana M. Cristea
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mSystems, Vol 6, Iss 3 (2021)
Druh dokumentu: article
ISSN: 2379-5077
DOI: 10.1128/mSystems.00397-21
Popis: Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.
Databáze: Directory of Open Access Journals