| Autor: |
Cristiane Marinho Uchôa Lopes, João Ricardhis Saturnino de Oliveira, Vanderlan Nogueira Holanda, Antonio Yony Felipe Rodrigues, Caíque Silveira Martins da Fonseca, Fábio Fernandes Galvão Rodrigues, Cicera Janaine Camilo, Vera Lucia de Menezes Lima, Henrique Douglas Melo Coutinho, Radosław Kowalski, José Galberto Martins da Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Separations, Vol 7, Iss 2, p 35 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2297-8739 |
| DOI: |
10.3390/separations7020035 |
| Popis: |
Clove (Syzygium aromaticum) is a spice widely used for its medical properties, though the species lacks scientific evidence regarding its toxicity and biologic effects. The aim of this study was the chemical identification by GC-MS analysis and evaluation of the hemolytic, anticoagulant, antidiarrheal and antipyretic activities of the essential oil from S. aromaticum (EOSa) in adult male mice. Essential oil was obtained by hydrodistillation and provided 9.8% v/w yield. GC-MS analyses allowed the identification of nine constituents, with eugenol (84.63%) as the majority. EOSa was diluted in several concentrations (0.005–2 mg/mL) for hemolytic assays, showing hemolytic activity above 20% in concentrations higher than 0.625 mg/mL. Different concentrations of EOSa induced a coagulation time 100% higher than control blood. 50 and 100 mg/kg of EOSa caused additional intestinal motility induced by castor oil by 90–100%. Fever, induced by Saccharomyces cerevisae 15% (s.c.), was controlled by 50 and 100 mg/kg EOSa (p.o.), effects similar to 100 mg/kg dypirone. Results showed that when used orally, EOSa may have a certain degree of toxicity in high dosages, but with antipyretic and intestinal motility properties. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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