| Autor: |
K. N. Alieva, E. N. Strukova, M. V. Golikova, Yu. A. Portnoy, A. A. Firsov |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 61, Iss 9-10, Pp 28-32 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| Popis: |
To establish the relationships between the enrichment of resistant Staphylococcus aureus mutants and the ratio of daily area under the concentration - time curve (AUC24) to the MIC of linezolid, a mixed inoculum of linezolid-susceptible and -resistant cells of three strains of S.aureus was exposed to twice daily linezolid in an in vitro dynamic model. Simulated pharmacokinetic profiles mimicked five-day treatments with linezolid dosing over a 32-fold range of the AUC24/MIC ratio. Population analysis of linezol-id-exposed staphylococci was performed daily over 120 h after the start of the treatments. Minor if any enrichment of mutants resistant to 2Х, 4Х and 8XMIC of antibiotic was observed at the lowest and the highest AUC24/MIC ratios in contrast to pronounced enrichment of resistant mutants at the intermediate AUC24/MICs. An integral parameter AUBCM, the area under the time course of resistance mutants, was shown to be a more appropriate endpoint to establish AUC24/MIC relationships with resistance than postexposure number of mutants (NM). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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