A case of primary clear cell hepatocellular carcinoma in a non-cirrhotic liver: an immunohistochemical and ultrastructural study
| Autor: | Zhanyong Bing, Pil Gyu Hwang, Yuan Yao, Theodore Xu, Amy Ziober, Erica Fan Clayton, Emma Elizabeth Furth |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Rare Tumors, Vol 4, Iss 2, Pp e29-e29 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2036-3605 2036-3613 |
| DOI: | 10.4081/rt.2012.e29 |
| Popis: | The clear cell variant of hepatocellular carcinoma is a rare entity, occurring at a frequency of less than 10% of hepatocellular carcinoma, with a female prevalence and usually associated with hepatitis C and cirrhosis. We reported a case of primary clear cell hepatocellular carcinoma occurring in a non-cirrhotic liver without history of hepatitis. Our examination included gross pathology, histopathology, immunohistochemistry, special stains, and electron microscopy evaluation. The tumor was composed of sheets of medium-to-large cells with foamy and reticulated cytoplasm and small-to-medium sized nuclei with variably prominent nucleoli. Oil red O stain showed abundant intracellular lipid. Periodic Acid- Schiff stain confirmed the presence of abundant glycogen deposition. Immunohistoche - mically the tumor cells were positive for Hep Par1, negative for epithelial membrane antigen, steroidogenic factor-1, HMB45, melan A, CK7 and CK20. Electron microscopy study was performed, which was first done in a clear cell hepatocellular carcinoma occurring in a noncirrhotic liver without elevation of liver function tests. Ultrastructural evaluation of the clear cells showed scarce cellular organelles, cytoplasmic lipid vacuoles and swollen mitochondria. |
| Databáze: | Directory of Open Access Journals |
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