The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress

Autor:	Mugahed Abdullah Hasan Albahde, Bulat Abdrakhimov, Guo-Qi Li, Xiaohu Zhou, Dongkai Zhou, Hao Xu, Huixiao Qian, Weilin Wang
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	pancreatic ductal adenocarcinoma microtubule-targeting agents microtubules pancreatic cancer drugs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Frontiers in Oncology, Vol 11 (2021)
Druh dokumentu:	article
ISSN:	2234-943X 03403688
DOI:	10.3389/fonc.2021.640863
Popis:	Pancreatic cancer has an extremely low prognosis, which is attributable to its high aggressiveness, invasiveness, late diagnosis, and lack of effective therapies. Among all the drugs joining the fight against this type of cancer, microtubule-targeting agents are considered to be the most promising. They inhibit cancer cells although through different mechanisms such as blocking cell division, apoptosis induction, etc. Hereby, we review the functions of microtubule cytoskeletal proteins in tumor cells and comprehensively examine the effects of microtubule-targeting agents on pancreatic carcinoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2963e95b3b034036883b1bf701349da1 Zobrazit plný text záznamu View record in DOAJ