Long-term impact of the metabolic status on weight loss-induced health benefits

Autor: Dominik Soll, Julia Gawron, Laura Pletsch-Borba, Joachim Spranger, Knut Mai
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nutrition & Metabolism, Vol 19, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 1743-7075
DOI: 10.1186/s12986-022-00660-w
Popis: Abstract Background While short-term effects of weight loss on quality of life and metabolic aspects appear to be different in metabolically healthy (MHO) and metabolically unhealthy obese (MUO), respective long-term data is still missing. Given the high relevance of long-term changes, we aimed to address these in this post-hoc analysis of the MAINTAIN trial. Methods We analyzed 143 overweight/obese subjects (BMI ≥ 27 kg/m2, age ≥ 18 years) before and after a 3-month weight loss program (≥ 8% weight loss), after a 12-month period of a randomized weight maintenance intervention (n = 121), and after another 6 months without intervention (n = 112). Subjects were retrospectively grouped into MHO and MUO by the presence of metabolic syndrome and secondarily by estimates of insulin sensitivity (HOMA-IR and ISIClamp). Quality of life (QoL), blood pressure, lipids, HOMA-IR, and ISIClamp were assessed and evaluated using mixed model analyses. Results Despite similar short- and long-term weight loss, weight loss-induced improvement of HOMA-IR was more pronounced in MUO than MHO after 3 months (MHO: 2.4[95%-CI: 1.9–2.9] vs. 1.6[1.1–2.1], p = 0.004; MUO: 3.6[3.2–4.0] vs. 2.0[1.6–2.4], p
Databáze: Directory of Open Access Journals
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