Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile

Autor:	Kothapalli Nagamounika, Josna Joseph, R Hemanth Kumar, John Mathew
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	diagnosis hydroxy-3-methyl-glutaryl-coenzyme a reductase antibody immune-mediated necrotizing myopathy myositis Diseases of the musculoskeletal system RC925-935
Zdroj:	Indian Journal of Rheumatology, Vol 18, Iss 2, Pp 166-169 (2023)
Druh dokumentu:	article
ISSN:	0973-3698 0973-3701
DOI:	10.4103/injr.injr_82_22
Popis:	Statin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker. In this context, this case, which is the first one reported from a tertiary care center in South India, is unique. The presence of hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody supplements the clinical diagnosis, specifically in the serological absence of myositis-specific antibodies. A comprehensive diagnostic approach including HMGCR antibody positivity is advisable in IMNM.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/294b5baac835469fb3b965028f7e2c28 Zobrazit plný text záznamu View record in DOAJ