A computational exploration of resilience and evolvability of protein–protein interaction networks

Autor: Brennan Klein, Ludvig Holmér, Keith M. Smith, Mackenzie M. Johnson, Anshuman Swain, Laura Stolp, Ashley I. Teufel, April S. Kleppe
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02867-8
Popis: Brennan Klein et al. propose an adapted network resilience measure, the prospective resilience (PR), to explore the resilience of protein–protein interaction networks following addition of new nodes. They apply PR to public datasets and find that resilience of a network is maximized when attachment of new nodes, or proteins, is based on the gene expression levels of the existing proteins in the network.
Databáze: Directory of Open Access Journals