The Effect of Omega-3 on the Level of Serum Lipid Profile, Adipocytokines, and Indicator of Vascular Inflammation in Patients Diagnosed with Myocardial Infarction
| Autor: | Fatemeh Haidari, Mahshid Tavakoli, Habib Heybar, Bijan Helli, Majid Mohamadshahi |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 17, Iss 4, Pp 7-17 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | BACKGROUND AND OBJECTIVE: Changes in inflammatory mediators have an important role in myocardial infraction. Since the anti-inflammatory effects of Omega-3 fatty acids on cardiovascular diseases was reported, this study was done to evaluate the Omega-3 effect on serum lipid profile, leptin, adiponectin, and E-selectin in patients with myocardial infraction. METHODS: In this double blinded clinical trial study, 42 patients with myocardial infraction were randomly divided into two mediator and control group. For 10 weeks, the mediator group received 3 capsules of 1 gram Omega-3 daily, and the control group received 3 capsules of placebo (paraffin) daily. Concentration of serum lipid profile, leptin, adiponectin, and E-selectin was measured and compared at the beginning and at the end of the test. IRCT=2021070410181N1 FINDINGS: At the end of the study, after comparing the Omega-3 receiving group with placebo group, there was a significant decrease of serum level of triglyceride (120.04±53.24 versus 150.76±48.84, p=0.021), leptin (6.92±2.71 versus 9.05±2.66, p=0.007), and E-selectin (20.98±10.04 versus 6.55±4.12), and there was a significant increase in the serum level of adiponectin (7.24±3.50 versus 6.55±4.12, p=0.026) in patients with myocardial infraction. In both groups, improvement in the size of blood lipids (TC, LDL-C, HDL-C) was obvious when compared to the primary sizes (p |
| Databáze: | Directory of Open Access Journals |
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