Involvement of proinflammatory S100A9/A8 in the atherocalcinosis of aortic valves
| Autor: | R. А. Moskalenko, А. M. Romaniuk, I. O. Iashchishyn, I.-M. S. Zakorko, А. M. Piddubnyi, Ye. O. Chernov, L. O. Morozova-Roche |
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| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Patologìâ, Iss 1, Pp 49-56 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2310-1237 2306-8027 |
| DOI: | 10.14739/2310-1237.2017.1.98183 |
| Popis: | Abstract According to the results of the Euro-Heart Survey on Vascular Heart Disease the most common pathology is nonrheumatic aortic stenosis, it is also called as calcific aortic valve stenosis (CAVS), as in its pathogenesis the process of biomineralization of valve cusps and ring plays the main role. The aim of the work is the immunohistochemical study of mineralized tissue of aortic heart valves, which are affected by atherocalcinosis. Materials and methods. 30 samples of mineralized aortic valves (I group) and 10 samples of aortic valve without evidence of biomineralization (II group -– control) were studied. Immunohistochemical study of expression of collagen (Collagen I), CD68, myeloperoxidase (MPO), calgranulin A (S100A8), calgranulin B (S100A9), caspase 3 (Casp 3) and osteopontin (OPN) was conducted in AV tissue of both groups. Results. In CAV tissues the fibrillar component (collagen I) growths was found, but the quantitative and qualitative compositions of CD68+ circulating inflammatory cells are not significantly different from the control group. CAVs contain much more MPO+ -cells (p |
| Databáze: | Directory of Open Access Journals |
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