Prevalence and metabolic risk factors of chronic kidney disease among a Mexican adult population: a cross-sectional study in primary healthcare medical units

Autor: Alfonso R. Alvarez Paredes, Anel Gómez García, Martha Angélica Alvarez Paredes, Nely Velázquez, Diana Cindy Ojeda Bolaños, Miriam Sarai Padilla Sandoval, Juan M. Gallardo, Gerardo Muñoz Cortés, Seydhel Cristina Reyes Granados, Mario Felipe Rodríguez Morán, Joaquin Tripp, Arturo Lopez Pineda, Cleto Alvarez Aguilar
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PeerJ, Vol 12, p e17817 (2024)
Druh dokumentu: article
ISSN: 2167-8359
DOI: 10.7717/peerj.17817
Popis: Introduction The intricate relationship between obesity and chronic kidney disease (CKD) progression underscores a significant public health challenge. Obesity is strongly linked to the onset of several health conditions, including arterial hypertension (AHTN), metabolic syndrome, diabetes, dyslipidemia, and hyperuricemia. Understanding the connection between CKD and obesity is crucial for addressing their complex interplay in public health strategies. Objective This research aimed to determine the prevalence of CKD in a population with high obesity rates and evaluate the associated metabolic risk factors. Material and Methods In this cross-sectional study conducted from January 2017 to December 2019 we included 3,901 participants of both sexes aged ≥20 years who were selected from primary healthcare medical units of the Mexican Social Security Institute (IMSS) in Michoacan, Mexico. We measured the participants’ weight, height, systolic and diastolic blood pressure, glucose, creatinine, total cholesterol, triglycerides, HDL-c, LDL-c, and uric acid. We estimated the glomerular filtration rate using the Collaborative Chronic Kidney Disease Epidemiology (CKD-EPI) equation. Results Among the population studied, 50.6% were women and 49.4% were men, with a mean age of 49 years (range: 23–90). The prevalence of CKD was 21.9%. Factors significantly associated with an increased risk of CKD included age ≥60 years (OR = 11.70, 95% CI [9.83–15.93]), overweight (OR = 4.19, 95% CI [2.88–6.11]), obesity (OR = 13.31, 95% CI [11.12–15.93]), abdominal obesity (OR = 9.25, 95% CI [7.13–11.99]), AHTN (OR = 20.63, 95% CI [17.02–25.02]), impaired fasting glucose (IFG) (OR = 2.73, 95% CI [2.31–3.23]), type 2 diabetes (T2D) (OR = 14.30, 95% CI [11.14–18.37]), total cholesterol (TC) ≥200 mg/dL (OR = 6.04, 95% CI [5.11–7.14]), triglycerides (TG) ≥150 mg/dL (OR = 5.63, 95% CI 4.76-6.66), HDL-c
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