| Autor: |
Manoel T. Rodrigues Jr., Aline S. B. de Oliveira, Ralph C. Gomes, Amanda Soares Hirata, Lucas A. Zeoly, Hugo Santos, João Arantes, Catarina Sofia Mateus Reis-Silva, João Agostinho Machado-Neto, Leticia Veras Costa-Lotufo, Fernando Coelho |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1167-1178 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.20.99 |
| Popis: |
We describe the use of bismuth(III) triflate as an efficient and environmentally friendly catalyst for the Nazarov reaction of aryl vinyl ketones, leading to the synthesis of 3-aryl-2-ethoxycarbonyl-1-indanones and 3-aryl-1-indanones. By changing the temperature and reaction time, it was possible to modulate the reactivity, allowing the synthesis of two distinct product classes (3-aryl-2-ethoxycarbonyl-1-indanones and 3-aryl-1-indanones) in good to excellent yield. The reaction did not require additives and was insensitive to both air and moisture. Preliminary biological evaluation of some indanones showed a promising profile against some human cancer line cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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