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Objectives: The aim of the study was to assess the possible associations among biochemical parameters that may be correlated with the possible mechanisms of iron metabolism in healthy children with normal body mass index (BMI), along with morbid obese (MO) children with and without metabolic syndrome (MetS). Methods: To this end, children aged 6-18 years with no history of any acute or chronic diseases were selected as the population of this prospective case-control study. Thirty MO children (with BMI higher than 99th percentile and without MetS findings), 28 MO children (with BMI higher than 99th percentile and with MetS), and 30 healthy children (with BMI values between 15th and 85th percentiles) participated in the study. Then, anthropometric measurements were recorded, followed by performing the complete blood count and serum iron profile. In addition, ferritin, transferrin, hepcidin, irisin, ferroportin, brain-derived neurotrophic factor (BDNF), WISP1, and PTP1/fortilin levels were measured using ELISA. Finally, statistical analyses were performed and P |
