Distribution of Major Histocompatibility Complex Alleles in Cohorts of Patients with Different Levels of Post-Vaccination Antibodies against Hepatitis B
| Autor: | N. V. Vlasenko, M. D. Chanyshev, A. V. Peresadina, A. A. Grishaeva, T. A. Semenenko, A. V. Snitsar, L. V. Lyalina, S. N. Kuzin, K. F. Khafizov, V. G. Akimkin |
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| Jazyk: | ruština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Эпидемиология и вакцинопрофилактика, Vol 23, Iss 3, Pp 76-87 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2073-3046 2619-0494 |
| DOI: | 10.31631/2073-3046-2024-23-3-76-87 |
| Popis: | Relevance. It is known that the immune response to the administration of immunobiological drugs is variable and depends on the individual characteristics of the organism. Host immunogenetic factors have a significant impact on the effectiveness of vaccination. In this study, the frequencies of alleles of the HLA class I (HLA-A, B, C) and class II genes (HLA-DRB1, DPB1, DQB1) were studied in groups of participants with different levels of antibodies (anti-HBs) after vaccination against viral hepatitis B. Aims of the work was to determine the possible relationship between alleles of HLA genes and the intensity of post-vaccination immunity against hepatitis B. Materials and methods. The study included 271 apparently healthy adults who were divided into 3 groups depending on the specific concentration of post-vaccination antibodies (anti-HBs) using ELISA. All calculations were made relative to the groups anti-HBs >100 mIU/ml (n=82), 10-100 mIU/ml (n=98) (protective antibody level) and anti-HBs |
| Databáze: | Directory of Open Access Journals |
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