| Autor: |
Dengxiong Li, Fanglin Shao, Qingxin Yu, Ruicheng Wu, Zhouting Tuo, Jie Wang, Luxia Ye, Yiqing Guo, Koo Han Yoo, Mang Ke, Uzoamaka Adaobi Okoli, Chaipanichkul Premkamon, Yubo Yang, Wuran Wei, Susan Heavey, William C. Cho, Dechao Feng |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1478-811X |
| DOI: |
10.1186/s12964-024-01776-7 |
| Popis: |
Abstract Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within the tumor microenvironment (TME) have deepened our understanding of the mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug resistance suggesting that targeting the TME could be a viable strategy to combat this issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, and angiogenesis, contribute to drug resistance could be a viable strategy to combat this issue. Overexpression of STAT3 is commonly associated with drug-resistant cancer cells or stromal cells. Current research often generalizes the impact of stromal cells on resistance, lacking specificity and statistical robustness. Thus, future research should take notice of this issue and aim to provide high-quality evidence. Despite the existing limitations, targeting the TME to overcome therapy resistance hold promising and valuable potential. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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