Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome

Autor: Tina Roostaei, Hans-Ulrich Klein, Yiyi Ma, Daniel Felsky, Pia Kivisäkk, Sarah M. Connor, Alexandra Kroshilina, Christina Yung, Belinda J. Kaskow, Xiaorong Shao, Brooke Rhead, José M. Ordovás, Devin M. Absher, Donna K. Arnett, Jia Liu, Nikolaos Patsopoulos, Lisa F. Barcellos, Howard L. Weiner, Philip L. De Jager
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27427-w
Popis: Integrating functional data with GWAS loci can help interpret the function of genetic variants associated with disease. Here the authors map cis and trans methylation QTL in CD4 + T cells from patients and colocalize with GWAS loci in order to interpret genetic variants associated with multiple sclerosis.
Databáze: Directory of Open Access Journals