A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

Autor: Kim S. de Valk, Henricus J. Handgraaf, Marion M. Deken, Babs G. Sibinga Mulder, Adrianus R. Valentijn, Anton G. Terwisscha van Scheltinga, Joeri Kuil, Michiel J. van Esdonk, Jaap Vuijk, Rob F. Bevers, Koen C. Peeters, Fabian A. Holman, John V. Frangioni, Jacobus Burggraaf, Alexander L. Vahrmeijer
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11014-1
Popis: Iatrogenic injury of the ureters is a feared complication of laparoscopic abdominal surgery. Here the authors present the NIR fluorophore ZW800-1 as an intraoperative imaging agent for ureter mapping, showing its safety, pharmacokinetic properties, and efficacy in healthy volunteers and patients undergoing abdominopelvic surgery.
Databáze: Directory of Open Access Journals