Immobilization of Chaga extract in alginate beads for modified release: Simplicity meets efficiency
| Autor: | Petrović Predrag, Ivanović Katarina, Octrue Charly, Tumara Mića, Jovanović Aleksandra, Vunduk Jovana, Nikšić Miomir, Pjanović Rada, Bugarski Branko, Klaus Anita |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Hemijska Industrija, Vol 73, Iss 5, Pp 325-335 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0367-598X 2217-7426 95701265 |
| DOI: | 10.2298/HEMIND190819028P |
| Popis: | Chaga (Inonotus obliquus) is a parasitic fungus, which has been used in traditional medicine in Russia and other northern European countries in the treatment of cancer, gastrointestinal andliver diseases. It has been a subject of intensive researchrecently, confirming many of its health-beneficial effects. In order to obtain a product that would allow modified and prolonged release of the Chaga’s active metabolites, hot water Chaga extract was immobilized using calcium - alginate. The extract, which was predominantly composed of carbohydrates (57 %), also contained a relatively high amount of antioxidants/phenolic compounds (130 mg gallic acid equivalents per g of dry extract) and exhibited pronounced radical scavenging activity. It showed significant antibacterial activity as well, inhibiting growth of tested bacterial strains at concentrations of 1.25-20 mg/mL. Entrapment efficiency was about 80 %, and the extract-alginate system showed pH-dependant extract release; there was negligible release at pH 1.75 (gastric pH), and the release gradually increased with the increase in pH, reaching ~43 % of immobilized extract at pH 8.5 after 90 min. Such a product could be used as a dietary supplement, adjuvant in therapy of gastrointestinal diseases or as a food additive. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III46010] |
| Databáze: | Directory of Open Access Journals |
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