Garlic-induced Stable Black Gold Nanostructure: Optical, Morphological, Antibacterial, Antioxidant and Cytotoxic properties
| Autor: | Harits Atika Ariyanta, Hotlina Nainggolan, Siti Aysah Denti, Yega Segara M, Cahya Mukti Setiyanto, Indila Mayrosa, Widya Fatriasari, Yoki Yulizar, Tribidasari A. Ivandini |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | International Journal of Technology, Vol 15, Iss 4, Pp 965-975 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2086-9614 2087-2100 |
| DOI: | 10.14716/ijtech.v15i4.6147 |
| Popis: | We have successfully developed a direct, one-step phyto-synthesis of stable black gold nanostructure (AuNS) using garlic extract (GE). The presence of abundant S in GE has a high affinity for Au, forming strong Au-S bonds to induce the growth of anisotropic crystals on Au and continue to form an extensive network of nanowires resembling a dendrimer. The synthesized garlic-induced stable black AuNS was observed by a color change from brick-red to black through the addition of GE at various concentrations and confirmed by the UV–Vis spectrophotometer, particle size analyzer (PSA), transmission electron microscope (TEM), Fourier transform infrared (FTIR), and x-ray diffraction (XRD) spectrophotometer. In addition, the antibacterial, antioxidant, and cytotoxic properties of the black AuNS were studied. Black-AuNs showed no antibacterial activity on gram-negative bacteria (Escherichia coli) and two gram-positive bacteria (Staphylococcus aureus and Bacillus subtilisin) but had very high antioxidant activity (99.68% DPPH inhibition). The cytotoxic effect of black-AuNS was studied in normal cells and showed that the inhibition in both Vero and Chang cells was dose-dependent. These findings offer new opportunities to develop a “green” superstructure of black AuNS for other biomedical applications. |
| Databáze: | Directory of Open Access Journals |
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