| Autor: |
Ying Chen, Tingting Niu, Ting Chen, Yue Wu, Duobing Zou, Cong Shi, Ying Wu, Zhaoyi Zhang, Ningning Wu, Yi Zhang, Xiao Yan, Lixia Sheng, Dingfeng Lv, Guifang Ouyang, Xueqin Chen, Qitian Mu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Nutrition, Vol 10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2296-861X |
| DOI: |
10.3389/fnut.2023.1125768 |
| Popis: |
BackgroundThis study aims to investigate the prognostic significance of transthyretin in newly diagnosed myelodysplastic syndromes (MDS).MethodsThe clinical, laboratory, and follow-up data of 280 newly diagnosed patients with MDS were collected. The relationship between serum transthyretin levels and overall survival (OS) and leukemia-free survival (LFS) were analyzed by Kaplan–Meier analysis and Cox Regression Model.ResultIn the MDS cohort, there were 121 cases in the low transthyretin group and 159 cases in the normal transthyretin group. MDS patients with decreased transthyretin had a higher risk score on the Revised International Prognostic Scoring System (IPSS-R) (p = 0.004) and on the molecular IPSS (IPSS-M) (p = 0.005), a higher frequency of TP53 mutation (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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