Reactivation of occult hepatitis B virus infection in a renal transplant recipient

Autor:	Lili Jiang, Huiqi Wang, Yaping Huang, Hanying Liang, Xiaodong Wang, Jun Fan
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	HBV reactivation Occult infection HBV escape mutant Immunity Renal transplantation Infectious and parasitic diseases RC109-216
Zdroj:	Virology Journal, Vol 19, Iss 1, Pp 1-6 (2022)
Druh dokumentu:	article
ISSN:	1743-422X
DOI:	10.1186/s12985-022-01946-4
Popis:	Abstract We report a case of hepatitis B virus (HBV) reactivation in a renal transplant recipient. Reactivation manifested as an occult infection with detectable HBV-DNA and negativity for hepatitis B surface antigen (HBsAg). The anti-HBs antibody titre was above the protective threshold and continued to rise, to 951.36 mIU/ml, after HBV reactivation. Sequencing revealed multiple vaccine- and diagnostic-escape mutations in the major hydrophilic region of HBsAg. This case demonstrates both reactivation of an HBV escape mutant in a vaccinated patient and host immunity after virus mutation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/28ec5b469e99456ca11618a5a5aaafca Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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