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Objective To investigate the risk factors for severe hyperlactacidemia after liver transplantation, and to provide a basis for adopting effective preventative strategies in clinical practice. Methods A retrospective analysis was performed for the clinical data of 120 patients who underwent liver transplantation in our hospital from January to December, 2021, and according to the value of arterial lactic acid (LAC) after surgery, they were divided into severe hyperlactacidemia group and non-severe hyperlactacidemia group. The trend line chart was plotted to analyze the association between blood biochemical parameters and arterial LAC level in the perioperative period; the chi-square test, the t-test, the non-parametric test, and the multivariate logistic regression model analysis were used to investigate the effect of the above indicators on severe hyperlactacidemia after liver transplantation. Results The trend line chart showed that in all patients, the changing trend of serum alanine aminotransferase, serum aspartate aminotransferase, serum albumin, plasma international normalized ratio, and prothrombin time was consistent with that of arterial LAC level from day 3 before surgery to day 3 after surgery. The univariate analysis showed that there were significant differences between the two groups in the constituent ratio of primary disease, duration of anhepatic phase during surgery, total intraoperative intake, intraoperative blood loss, and intraoperative red blood cell transfusion (χ2=10.579,U=-2.811--2.183,P |
