HIV and CKD in the Tenofovir Era: A Prospective Parallel-Group Cohort Study From Tanzania

Autor: Nicholas L.S. Roberts, Salama Fadhil, Megan Willkens, Grace Ruselu, Bernard Desderius, Said Kanenda, Ladius Rudovick, Bazil B. Kavishe, Serena P. Koenig, Sri Lekha Tummalapalli, Myung Hee Lee, Robert N. Peck
Jazyk: angličtina
Rok vydání: 2025
Předmět:
Zdroj: Kidney Medicine, Vol 7, Iss 1, Pp 100937- (2025)
Druh dokumentu: article
ISSN: 2590-0595
DOI: 10.1016/j.xkme.2024.100937
Popis: Rationale & Objective: Longitudinal research on chronic kidney disease (CKD) in sub-Saharan Africa is sparse, especially among people living with HIV (PLWH). We evaluated the incidence of CKD among PLWH compared with HIV-uninfected controls in Tanzania. Study Design: Prospective cohort study. Setting & Participants: A total of 495 newly diagnosed PLWH who initiated antiretroviral therapy (ART) and 505 HIV-uninfected adults enrolled from public HIV clinics and followed from 2016-2021. The control group was recruited from HIV treatment partners from the same HIV clinics. Exposures: Untreated HIV (at baseline), ART, sociodemographic information, health behaviors, hypertension, and diabetes. Outcomes: Incident CKD, defined as a follow-up estimated glomerular filtration rate (eGFR) of
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