| Autor: |
Neil K Jairath, Redina Bardhi, John S Runge, Ramona Bledea, Ruple Jairath, Yang Wang, Matthew Patrick, Ryan A Wilcox, Alexandra C Hristov, Lam C Tsoi, Trilokraj Tejasvi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 17, Iss 11, p e0277655 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0277655 |
| Popis: |
BackgroundLarge cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its development.ObjectivesHere, we seek to characterize the clinicopathologic risk factors that predispose patients with SS to develop LCT.MethodsWe retrospectively evaluated all SS patient records available in the Michigan Medicine Cancer Registry from 2010-2021. Clinical and pathologic variables were compared between groups. The Kaplan-Meier method and log-rank test were used to assess overall survival.ResultsOf 28 SS patients identified, eight patients experienced LCT, and 20 did not (NLCT). Peak lactate dehydrogenase (LDH) before LCT (p = 0.0012), maximum total body surface area (TBSA) involvement before LCT (p = 0.0114), absolute CD8+ cell count measured on flow cytometry at diagnosis of SS (p = 0.0455) and at the most recent blood draw (p = 0.00736), and ulceration on biopsy (p = 0.0034) were significant clinicopathologic variables identified between the SS patients that developed LCT versus those that did not.ConclusionsMaximum TBSA involvement, peak LDH, presence of ulceration, and decreased levels of CD8+ cells in the peripheral blood may predict the development of LCT in patients with SS. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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