The emerging role of RNA N6-methyladenosine methylation in breast cancer

Autor: Fangchao Zheng, Feng Du, Jiuda Zhao, Xue Wang, Yiran Si, Peng Jin, Haili Qian, Binghe Xu, Peng Yuan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biomarker Research, Vol 9, Iss 1, Pp 1-15 (2021)
Druh dokumentu: article
ISSN: 2050-7771
DOI: 10.1186/s40364-021-00295-8
Popis: Abstract N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.
Databáze: Directory of Open Access Journals