| Autor: |
Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-018-06125-0 |
| Popis: |
The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby decreasing microbial butyrate and its protective effects on colitis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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