The evolutionary safety of mutagenic drugs should be assessed before drug approval.

Autor: Gabriela Lobinska, Vyacheslav Tretyachenko, Orna Dahan, Martin A Nowak, Yitzhak Pilpel
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PLoS Biology, Vol 22, Iss 3, p e3002570 (2024)
Druh dokumentu: article
ISSN: 1544-9173
1545-7885
32851855
DOI: 10.1371/journal.pbio.3002570&type=printable
Popis: Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such treatments.
Databáze: Directory of Open Access Journals
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