Comparison of GWAS results between de novo tinnitus and cancer treatment-related tinnitus suggests distinctive roles for genetic risk factors

Autor:	Mohammad Shahbazi, Heather E. Wheeler, Gregory T. Armstrong, Robert D. Frisina, Lois B. Travis, M. Eileen Dolan
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Tinnitus Genetic-risk UK-Biobank GWAS Radiotherapy Cisplatin Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-78274-w
Popis:	Abstract Tinnitus is a common sensorineural complication that can occur de novo or after cancer treatments involving cisplatin or radiotherapy. Considering the heterogeneous etiology and pathophysiology of tinnitus, the extent to which shared genetic risk factors contribute to de novo tinnitus and cancer treatment-induced tinnitus is not clear. Here we report a GWAS for de novo tinnitus using the UK Biobank cohort with nine loci showing significantly associated variants (p
Databáze:	Directory of Open Access Journals
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